DIAGNOSIS AND TREATMENT OF EXOTIC DISHES

File: 121096_sep96_decls39_0006.txt
Page: 0006
Total Pages: 24

Subject: DIAGNOSIS AND TREATMENT OF EXOTIC DISHES                        

Unit: OTSG        

Parent Organization: HSC         

Box  ID: BX003203

Folder Title: DIAGNOSOS AND TREATMENT OF EXOTIC DISEASES                                                      

Document Number:          1

Folder Seq  #:        180







                 Almost all cases of inhalation anthrax have been fatal regardless
           treat3nent. Historically, penicillin has been regarded as the treat3nent o         :e,
           with 2 million units given intravenously every 2 hours. Tetracycline ai
           erythromycin have been recommended in peniciuin-sensitive patients. I              t
           majority of anthrax s@ are sensitive in @ to penicillin. Howevei
           penic@-resistant s@ exist naturally, and one has been recovered f
           fatal human case. Moreover, it is not difficult to induce resistance to t
           penicillin and tetracycline through laboratory manipulation of organism
           strains tested to date have been sensitive to erythromycin, chloramphen
           gentamicin, and ciprofloxacin. In the current setting, treatment should
           instituted at the earliest signs of disease with oral ciprofloxacin (1000 in
           initially, followed by 750 mg po bid) or intravenous doxycycline (200 i
           initially, followed by 100 mg q 12 hrs).
                 D. PROPHYLAXIS

                 VACCINE
                 A licensed, alum-precipitated, preparation of purified Bacillus Mi
           protective antigen (PA) has been shown to be effective in preventing or
           significantly reducing the incidence of inhalation anthrax. Limited humi
           suggests that, after completion of the first 3 doses of the recommended
           primary series (0,2,4 weeks, then 6,12,18 months), protection against t
           cutaneous and inhalation anthrax is afforded. Studies in rhesus monkeyt            ite
           that good protection is afforded after 2 doses (10-16 days apart) for per
           to 2 years. There is likely protection after 2 doses in humans as well,            re
           is too little information to draw firm conclusions. As with all vaccines.
           degree of protection depends upon the magnitude of the challenge dose;
ly overwhelmed by extremely bL

Document 24 f:/Week-36/BX003203/DIAGNOSOS AND TREATMENT OF EXOTIC DISEASES/diagnosis and treatment of exotic dishes:12069615360440
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003203
Unit = OTSG
Parent Organization = HSC
Folder Title = DIAGNOSOS AND TREATMENT OF EXOTIC DISEASES
Folder Seq # = 180
Subject = DIAGNOSIS AND TREATMENT OF EXOTIC DISHES
Document Seq # = 1
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 06-DEC-1996