RATIONALE ANTIBIOTICS PROPHYLAXIS AGAINST INHALATION ANTHRAX

File: 120396_sep96_decls28_0004.txt
Page: 0004
Total Pages: 8

Subject: RATIONALE ANTIBIOTICS PROPHYLAXIS AGAINST INHALATION ANTHRAX    

Unit: OTSG        

Parent Organization: HSC         

Box ID: BX003203

Folder Title: RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX                             

Document Number:          1

Folder SEQ  #:          5




                                   LIU nL I     UNCLASSIFIED
          &ntibatics were discontinued, 3. DOXYcyclins and ciprotloxacin
          may have offered some advantage over penicillin in this
          (inhalation anthrax) setting, and 4. c=bined antibiotics and
          vaccination in the post-axpcsurs period resulted in the bast
          s@ival.



              A simplified review of pathogenesis coupled with speculation
          about mechanism of antibiotic activity might shad light on the
          observed findings. Anthrax organisms are most effectively
          delivered by inhalation in the form of spares. inhalation of
          these spores results in sesding of terminal respiratory
          branchioles. spores than are phaqo@osed by alveolar
          macrophaqes and transported to lymphatic organs in the chest
          (pulmonary and mediastinal lymph nodes) and elsewhere. There,
          the spores germinate, becoming "vegetative" organisms which
          release toxins and exert adverse physiologic affect$. With
          continued replication of these ''vegetative'' bacilli, increasingly
          larger numbers of organisms and their toxins circulate. Finally,
          the host in overwhelmed and de&= ensues. with administration of
          appropriate antibiotics, vegetative forms (= spores) are
          killed. in some cases, this may be adequate for a "cure."  in
          many others, however, additional spores probably remain do=ant
          until antibiotics are discontinued. in these individuals,
          residual spores then germinate, and the replicative process
          begins answ. Theoretically, these persons could remain on
          antibiotics for prolonged periods, and survive. in practice

                                        4






                               UNCLASSIFIED

Document 8 f:/Week-36/BX003203/RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX/rationale antibiotics prophylaxis against inhala:11089615091429
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003203
Unit = OTSG
Parent Organization = HSC
Folder Title = RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX
Folder Seq # = 5
Subject = RATIONALE ANTIBIOTICS PROPHYLAXIS AGAINST INHALA
Document Seq # = 1
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 08-NOV-1996