Biological Warfare Defence Medical Guidelines

File: doc61_05.txt
Page: 05
Total Pages: 8
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DEPOSITED IN ~LYEOLI OP ~LVEOL~R DUCTS NHERE THEY ~PE
PH~~OOCYTI"ED BY H"LVEOL~R M~CROPHH~G'ES ~ND C~RRIED TO MEDI~STIN~L


P~(3E C)3 RHIP~~~\\\\
LYMPH NODES.   ~ HEMORR~OICMEDI~STINITIS RESULTS      FOLLONED BY
B~CTEREM I H~ ~ND I NTR~V~SCUL~R MULTI FL I C~T ION OF ORO~N I SMS.
MENINOITIS OFTEN OCCURS ~S ~ P~RT OF THE OVERNHELMINO
SEPTICEMI~.     INH~L~TION ~NTHRH~X IS VERY DIFFICULT TO DI~ONOSE
E~RLY. `THE DISE~SE IS BIPH~SIC. ~ND INITI~L SYMPTOMS MIMIC ~
SEVERE VIR~L RESPIR~TORY ILLNEcc LI~:E INFLUEN~.     THIS L~STS FOR
2 TO 3 D~YS ~ND IS FOLLONED BY ~ SECOND MORE H'~CUTE PH~SE
CH~R~CTERt~ED BY SEVERE HYPOXI~ ~ND DYSPNE~.     CHEST X-R~Y FILMS
CONSISTENTLY SHON NIDENINO OF THE MEDI~STINUM.     P~TIENTS SOON
E'ECOME HYPOTENSIVE, ~ND ~BOUT ONE-H~LF DEVELOP MENIN6E~L SIONS.
    B~CILLUS ~NTHR~CIS CELLS ~RE L~RGE, GR~M-POSITIVE B~CILLI ~ND
INDIVIDU4L CELLS H~VE SOU~RE OR CONC~VE ENDS.      OVOID.
SUBTERMIN~L ENDOSPORES TH~T DO NOT C~USE H~NY SIGNIFIC~NT
SNELLING OF THE CELLS M~Y BE OBSERVED.     THE SPORES ~PPE~R ~S
UNST~INED ~RE~S NITHIN THE B~CTERI~L CELLS IN OR~M'S ST~INED
PREP~R~TION.   THE ORG~NISM ORONS NELL ON ORDIN~RY BLOOD ~O~R
NITHIN 18 TO 24 HOURS ~T 35 DEGREES CENTIGR~DE.     THE COLONIES
~RE TYPIC~LLY FL~T ~ND IRREGUL~R. 4 MM TO 5 MM IN DI~METER ~ND
IS NOT HEMOLYTIC ON SHEEP BLOOD ~G~R.


P~GE C)4 RHIP~~~\\\\


   THE HUM~N ~NTHR~X V~CCINE IS FD~ ~PPROVED ~ND CONCISTS OF
H'~LUM - P REC I P 1 T~TED PROTECTIVE ~NT I GEN FROM FERMENTOR CULTURES OF
TOXIGENIC    NON-ENC~PSUL~TED STR~INS OF B~CILLUS ~NTHR~CIS.   IT
CONT~INS FORM~LIN ~ND BEN~ETHONIUM CHLORIDE.

SIX PER CENT NILL EXPERIENCE MILD LOC~L DISCOMFORT ~T THE
INOCUL~TION SITE ~ND LESS TH~N ONE PER CENT NILL H~VE MORE
SEVERE LOC~L RE~CTION.   ~LL C~N EXPECT SOME BURNING ~T THE
INJECTION SITE FOR UP TO TNO MINUTES ~FTER INJECTION.     NO
(\N~PHY'LHrCTIC REH"CTIONS HflVE BEEN EXPERIENCED IN OVER 15,C)OC~


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