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File: doc61_04.txt
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R~~c.~YUi4 RH I P~~~2295 C)O5 1 5C)6-SSSS- - RH I HL)~~ RH II M~~ RH I UF~~ RUflCH~~
RUbOH~~ RUEF:jCs *RUHrJOHr~
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P 051444 J~N 91
FM USCINCCENT//CCSO//
TO RH II M~~/COMUSM~RCENT/ /56/i'
RUDCH~~/COMUS~RCENT M~IN//S6//
RHI UFHr~/USCENT~F Ft~D HL~~~S ELEMENT/ /5(3/ /
RUHGO~~/COMUSN~VCENT/ /5(3/ /
RUDOH~~/COMUSN~VLO(3SUPFOR/ /I'~9/ /
RH I H~~~/~OCCENT DEPLOY~D/ /5(3/ /
INFO RU~F::JCS/JCS \A~SH I NOTON DC/ /J4-LRC//
BT . . -
SECTION 2 O~ 3
USE. OF VECTORS (E.(3. - FLE~S MOSOiiITOS) IS
TECHNIC~LLY FE~SIBLE BUT THE PROBLEMS OF PRODUCTION MUCH L~SS
THE DIFFICULTIES IN T~R(3ETIN(3 ~RE OBVIOUS. ~EROSOLS H~VE THE
~DV~NT~(3E OF ROUTINE DELIVERY SYSTEMS (~RTILLERY ROCrETS.
H~EROSOLI~ERS) ~4ITH SPECIFIC T~R(3ETIN(3 H~ND INFECTIVE ROUTE TH~T -
COULD PRODUCE- R~PID C~SU~LTIES (RESPIR~TORY). ~EROSOLS MUST
INCLUDE~P4RTICLE~ 3~- 5 MICkONS IN SI~E IN ORDER TO RE~CH THE
PULMON~RY ~LVEOLI. INFECTIYE DOSES V~RY NITH THE ~(3ENT
PREDICTION C)F..THC~SE~~T RI~: NILL V~RY NI~~H THE ~(3ENT TH~
DELIVERY SYSTEM, THE NE~THER TERRHIN ETC.
4. . *).- SPECIFIC THRE~T ~(3ENTS
- ~NTHR~X: ~NT~R~X IS PRIM~RILY H DISE~SE OF HERBIVORES.-
HUM~NS BECOME INFECTED ~S THEY COME INTO CONT~CT NITH INFECTED
~NIMHLS OR THEIR PRODUCTS. THE ULTIM~TE RESERVOIR OF B~CILLUS
PH~(3E C)2 RHIP~~~\\\\
~NTHR~CIS IS THE SOIL, HONEVER, IT IS CLE~R TH~T SIMPLE SOIL
CONT~MIN~TION ~NITH ~NTHR~X SPORES DOES NOT NECESS~RYILY (3IVE
RISE TO C~SES ~ND TH~T CERT~IN METEOROLO(3IC~L CONDITION~ flRE
NECESS~RY. ~ VE(3ET~TIVE PH~SE IS NECESS~RY NHEREBY ~NTHR~X
SPORES MULTIPLY TO ~ DENSITY SUFFICIENT TO C~USE DISE~SE IN
~NtM~LS TH~T (3R~~E IN THE ~RE~. INH~L~TION ~NTHR~X OCCURS
N~TUR~LLY NHEN ~EROSOLS OF ~NTHR~X SPORES ~RE (3ENER~TED DURINO
THE E~RLY PROCESSIN(3 OF IMPORTED (3O~T H~IR. SINCE THE DISE~SE
FOLLONS INH~L~TION OF ~NTHR~X SPORES. IT IS NEVER SEEN ~S ~
RESULT OF CONT~CT NITH RECENTLY INFECTED ~NIM~LS.
VrRULENCE OF B~CILLUS ~NTHR~CIS IS DEPENDENT UPON PL~SMID-
MEDI~TED PRODUCTION OF ~ THREE-COMPONENT EXOTOXIN ~ND ~N ~NTI-
PH~(3OCYTIC C~PSULE. THE TOXIC PROTEINS COLLECTIVELY REFERRED
TO~~S *~NTHR~X TOXIN,~ H~VE BEEN PURIFIED ~ND CLONED ~ND CONSIST
OF ~ PROTECTIVE ~NTI(3EN (P~) ~N EDEM~ F~CTOR (EF). ~ND ~ LETH~L
FHCTOR ~(L~) . -- INH~LED ~`1T~HF~~X SF~RES TH~T ~E (3REH~TER TH~N 5 UM
POS~E NO PROBLEM, ~S THEY ~RE PHYSIC~LLY CLE~RED FROM THE LUl'J(3 BY
THE .h1dCOCfrf~rY ESC~L~'TOR SYSTEM~. SM~LiER P~RTICLES ~RE
. `.- ~ M. ~ `Ir - `Ir `Ir. `Ir `Ir `Ir `Ir `Ir `Ir `Ir `Ir `Ir `Ir `Ir
_ `Ir . `Ir
`Ir `Ir `Ir `1 `Ir `Ir `Ir `Ir `Ir `Ir `Ir `Ir `Ir `Ir `Ir. . ...`Ir `Ir `Ir `Ir `Ir `Ir `Ir `Ir `Ir `Ir `Ir `Ir `Ir
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