NERVE AGENT ANTIDOTE PRETREATMENT INTERACTONS ADVERSE EFFECT

File: 081296_jul96_decls39_0001.txt
Page: 0001
Total Pages: 2

Subject: NERVE AGENT ANTIDOTE PRETREATMENT INTERACTONS ADVERSE EFFECT    

Box  ID: BX000414

Document Number:         60

Folder Title: HISTORIANS  BACKGROUND MATERIAL FILES - MISC MSG READING FILES -  8 SEP 90                      

Folder Seq #:          4

Unit: ARCENT      

Parent Organzation: CENTCOM     


                              0                            0

  RCV MSG N      TIME     RADAY                                 RET MSG 0      PRIORITY
    9493S        0026     251196                                   D5636

  CINC DCINC CSM SJS JI   J2 J3 J4 JS J6 JB AG   AFLNO CIDC CECOM.LAO COMSEC AFNSEP
  ENG F@C IG JA LAO LIB   MCP MD MEDDAC MARDET   NAVIV.0 NAVLNO NAVMARCOR MEPS DJNSA
  PM PA POST RCAO RDC ROME 6MCD SADBU SSO TCC 4Ef3A)44MHD 81ST 335TH CH AIRMICS

  PTTUZYUW RUEADWD0003 2502327-UUUU--RHCGSRB*
  ZNR UUUUU
  P 08023OZ SEP 90
  FM DA WASHINGTON DC//DAmo-DDO-AOC//
  TO RHCGSRB/CIIJCFOR FT MCPHERSUN GA//FCMD//-
  RUFDAAA/CDR 7TH MEDCOM HEIDELBERG GE//AEMPE-PS//
  RUWTNFH/CDRUSAHSC FT SAM HOUSTON TX
  RUEBLEA/CDRARCENT MAIN RIYADH $A//AFRD-MD//
  RHCGSRS/CDRARCENT FT MCPHERSON GA//AFRD-MD//
  RUEOHVA/CDR18TH ABN CORPS FT BRAGG NC//AFZM-MD//
  INFO RUEADWD/DA WASHINGTON DC//DASG-MCO/DASG-PSP//
  BT
  UNCLAS
  SUBJECT: NERVE AGENT ANTIDOTE AND PRETREATMENT DRUG INTERACTIONS OR
             ADVERSE EFFECTS
  1, RECENT INQUIRIES TO THE ARMY SURCEDN GENERAL*S OFFICE HAVE
  INDICATED THE NEED FOR DISSEMINATION OF ADDITIONAL GUIDANCE AND
  INFORMATION ON NERVE AGENT ANTIDOTES AND PRETREATMENTS,
  SPECIFICALLY, CONCERNS HAVE BEEN RAISED AS TO WHETHER SOLDIERS ON
  MEDICATIONS FOR EXISTING MEDICAL PROBLEM$ (SUCH As HYPERTENSION
  OR BRONCHIAL ASTHMA) WOULD BE AT UNDUE RISK OF MEDICAL
  COMPLICATIONS IN THE EVENT THAT THE NERVE AGENT PRETREATMENT$ OR



  PAGE 02 RUEADVID0003 UNCLAS
  ANTIDOTES WERE ADMINISTERED ON THE BATTLEFIELD,
  2* THE NERVE AGENT ANTIDOTES (ATROPINE AND PRALIDOXIME CHLORIDE)
  WILL ONLY BE ADMINISTERED DURING THE TREATMENT DF A SYMPTOMATIC
  NERVE AGENT CASUALTY, ADVERSE EFFECTS (IF ANY) DUE TO ANTIDOTE
  INTERACTION WITH   EXISTING ANTI-HYPERTENSIVE OR BROCHUDIDLATING
  MEDICATIONS WILL   BE FAR OUTWEIGHED BY THE PHARMACOLOGIC BENEFITS
  OF THE ANTIDOTES   IN THE FACE OF POTENT CHOLINESTERASE INHIBITIDN
  BY NERVE AGENTS,
DOSES
  PRESCRIBED BY FM   8-285 C30 MG EVERY 8 HOURS) MAY INCREASE
  CHOLINERGIC TONE   IN THE BRONCHIAL SMOOTH MUSCULATURE* HOWEVERP
  IT IS ANTICIPATED THAT EVEN INDIVIDUALS WITH MILD AIRWAY
  HYPER-REACTIVITY WOULD NOT BE CLINICALLY AFFECTED BY THIS DOSE OF
  PB* THE LIKELIHOOD OF MISSION-DISRUPTIVE OR LIFE-THREATENING
  BRUCHOCONSTRICTION IN THESE SOLDIERS IS EXTREMELY REMOTE. BASED
  UPON THE PHARMACOLOGIC ACTION OF PBf THE PROBABILITY OF ADVERSE
  DRUG INTERACTIONS BETWEEN PB AND OTHER PHARMAC040GIC AGENTS Is
  LOW* HOWEVER, THERE ARE No DATA EVALUATING THE CONCOMITANT USE
  OF THIS DOSE OF PB WITH A VARIETY OF OTHER THERAPEUTIC AGENTS,
  4, AT PRESENTT THE INTRODUCTION OF NERVE AGENT ANTIDOTES OR



  PAGE 03 RUEADWD0003 UNCLAS
  PRETREATMENTS IN THE COMBAT ZONE DOES NOT IMPACT ON SOLDIERS'

Document 2 f:/Week-29/BX000414/HISTORIANS BACKGROUND MATERIAL FILES - MISC MSG READING FILES - 8 SEP 90/nerve agent antidote pretreatment interactons ad:08099611162372
Control Fields 17
File Room = jul96_declassified
File Cabinet = Week-29
Box ID = BX000414
Unit = ARCENT
Parent Organization = CENTCOM
Folder Title = HISTORIANS BACKGROUND MATERIAL FILES - MISC MSG READING FILES - 8 SEP 90
Folder Seq # = 4
Subject = NERVE AGENT ANTIDOTE PRETREATMENT INTERACTONS AD
Document Seq # = 72
Document Date =
Scan Date = 24-JUL-1996
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 09-AUG-1996