TOXICOLOGICAL RESEARCH VACCINE STORAGE AREA

File: 123096_sep96_decls53_0004.txt
Page: 0004
Total Pages: 19

Subject: TOXICOLOGICAL RESEARCH  VACCINE STORAGE AREA                    

Unit: OTSG        

Parent Organization: HSC         

Box  ID: BX003203

Folder Title: MEETING AT NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH                                           

Document Number:          1

Folder Seq  #:         91









          NCTR 14 August 1990. page 3


           These must be documented. Upon arrival at NCTR, the animals
          must be quarantined for 10 weeks, during which time they will be
          examined for ecto- and endo-parasites, receive 5 TB tests, and be
          tested for Herpes B virus. Anti-Shigella antibodies must fall
          below certain titers. Animals must be Herpes B negative and but
          they can have antibody titers to the virus. They must be
          parasite-free except for lung mites. A typical protocol will
          utilize 24 monkeys; 25 animals should be ordered for such a
          protocol. Ron Banks will prepare an SOP for the
          testing/acceptability criteria of shigella animals (prior to
          shipment to NCTR, after the 10 week Quarantine at NCTR, and
          following the post challenge quarantine). He will distribute the
          drafts to Tom Bucci, Bill Witt, Larry Hale and Mike Roy for
          comment and then prepare a final SOP.

          9. Late in the afternoon, Dan Brand, Mr. Cody Partridge, safety
          officer, Larry Hale and Mike Roy met at Building 14 to discuss
          the possibility of doing the preclinical Shigella studies in the
          Chem Defense area (Building 14B and 14C and renovated by USAMRDC)
          on a temporary basis. The primary issue is safety. Can the
          animal wastes be collected and transported to an autoclave in
          another building in a safe manner and can the animal cages be
          disinfected and moved to a cage washer in another building in a
          safe manner. Everyone agreed that it could be done as an interim
          solution, that SOPs must be written to guide the procedures; if
          these SoPs were followed, the studies could be performed in a
          safe manner and without adding too many more man-hours to the
          budget. Animals could be quarantined in room 14CI27 (or adjacent
          rooms) and challenge and vaccination studies could be performed
      in rooms 14Bl3O/l3l/l32. We could complete 3 or 4 shigella
          studies and the dengue neuovirulence study in this area in
          FY1991. Once Bill Witt has received rough drafts of protocols
          from Larry Hale and draft SOPs from Roy Banks, he (with the
          assistance of Cody Partridge) will write the draft SOPs to guide
          animal personnel in this area. These will be circulated to Larry
          Hale, Jack Knowles, Ron Banks, Tom Bucci and Mike Roy for comment
          and corrections. Bill Witt will then prepare the final SOP for
          animal care operations in these areas. They will probably have
          to be reviewed by the safety officer at USAMRDC.

          10. The afternoon session was a discussion of the Architectural
          and Engineering design and budget (A&E) for the Contingency
          Vaccine Storage Area and the Preclinical Vaccine Testing Area,
          areas I and III, respectively of Building 14. Thomas Bedick,
          Robert Davis, Cody Partridge, Bruce Rice and a representative of
          the NCTR contracts office were present. Three representatives of

Document 19 f:/Week-36/BX003203/MEETING AT NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH/toxicological research vaccine storage area:12179609285454
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003203
Unit = OTSG
Parent Organization = HSC
Folder Title = MEETING AT NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH
Folder Seq # = 91
Subject = TOXICOLOGICAL RESEARCH VACCINE STORAGE AREA
Document Seq # = 1
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 17-DEC-1996