MEDICAL COUNTERMEASURES AGAINST BIOLOGICAL MATERIAL

File: 123096_sep96_decls27_0021.txt
Page: 0021
Total Pages: 34

Subject: MEDICAL COUNTERMEASURES AGAINST BIOLOGICAL MATERIAL             

Unit: OTSG        

Parent Organization: HSC         

Box  ID: BX003203

Folder Title: FREEDOM OF INFORMATION ACT REQUEST 3106                                                         

Document Number:          1

Folder Seq  #:         28





                                         UNCLASSIFIED









           and possible, albeit somewhat more difficult, to induce
           tetracycline resistance. Therefore, if there is information
           indicating a biological weapon attack, prophylaxis with
           ciproflo-acin (500 mg po bid), or doxycycline (100 mg po bid)
           should begin. If unvaccinated, a single 0.5 ml dose of vaccine
           should also be given subcutaneously. Should the attack be
           confirmed as anthrax, antibiotics should be continued for at
           least 4 weeks in all exposed. In addition, two 0.5 ml doses of
           vaccine should be given 2 weeks apart in unvaccinated; those
           previously vaccinated with fewer than three doses should
           receive a single 0.5 ml booster, while vaccination probably is
           not necessary for those who have received the entire three-dose
           primary series. Upon discontinuation of antibiotics, patients
           should be closely observed; if clinical signs of anthrax occur,
           patients should be treated as indicated above. If vaccine is
           not available, antibiotics should be continued beyond 4 weeks
           until the patient can be closely observed upon discontinuation
           of therapy.




                                       BOTULISM



           CLINICAL SYNDRQME

             Botulism is caused by intoxication with the neurotoxin
           produced by Clostridium botulinum. The toxin is a protein with
           molecular weight of approximately 150,000, which binds to the
           presynaptic membrane of neurons at peripheral cholinergic
           synapses to prevent release of acetylcholine and block
           neurotransmission. The blockage is most evident clinically in
           the cholinergic autonomic nervous system and at the
           neuromuscular junction.

             A biological warfare attack with botulinum toxin delivered
expected to cause
           symptoms similar in most respects to those observed with
           foodborne botulism.

             Clinical Features: Symptoms of botulism may begin as early
           as 3-36 hours following exposure, or as late as several days.
           Initial symptoms include generalized weakness, lassitude, and
           dizziness. Diminished salivation with extreme dryness of the
           mouth and throat may cause complaints of a sore throat.


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                                        UNCLASSIFIED

Document 34 f:/Week-36/BX003203/FREEDOM OF INFORMATION ACT REQUEST 3106/medical countermeasures against biological mater:12179609282028
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003203
Unit = OTSG
Parent Organization = HSC
Folder Title = FREEDOM OF INFORMATION ACT REQUEST 3106
Folder Seq # = 28
Subject = MEDICAL COUNTERMEASURES AGAINST BIOLOGICAL MATER
Document Seq # = 1
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 17-DEC-1996