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Subject: MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIAL                     

Unit: OTSG        

Parent Organization: HSC         

Box  ID: BX003202

Folder Title: DOCUMENT LISTING FOR PROJECT BADGER                                                             

Document Number:          3

Folder Seq  #:          1




                                         UNCLASSIFIED









            inferred from animal studies. Use requires pretesting for
            sensitivity to animal serum (and desensitization for those
            allergic), and disadvantages include rapid clearance by immune
            elimination, as well as theoretical risk of serum sickness.




                              STAPHYLOCOCCAL      OTOXIN B





              Staphylococcal enterotoxin B (SEB) is one of the several
            exotoxins produced by Staphylococcus aureus, causing food
            poisoning when ingested.

              A biological warfare attack with aerosol delivery of SEB to
            the respiratory tract produces a distinct syndrome causing
            significant morbidity and potential mortality.

              CliniQAl Features. The disease begins 1-6 hours after
            exposure with the sudden onset of fever, chills, headache,
            myalgia, and non-productive cough. In more severe cases,
            dyspnea and retrosternal chest pain may also be present.
            Fever, which may reach 103-106 degrees F, has lasted 2-5 days,
            cough may persist 1-4 weeks. In many patients, nausea, which
            may be severe, vomiting, and diarrhea will also occur.
            Physical findings are often more unremarkable. Conjunctival
            injection may be present, and in the most severe cases, signs
            of pulmonary edema would be expected. The chest x-ray is
            generally normal, but in severe cases, there will be increased
            interstitial markings, atelectasis, and possible overt
            pulmonary edema. In moderately severe laboratory exposures,
            lost duty time has been greater than 2 weeks, but, based upon
            animal data, it is anticipated that severe exposures will
            result in fatalities.




                 Routipe LabogAtoKy Findi"A. Laboratory findings are
and
              elevated erythrocyte sedimentation rate.

              . niffarential Diagn@. In foodborne SEB intoxication,
              fever and respiratory involvement are not seen, and
              gastrointestinal symptoms are prominent.



                                           10
                                    UNC         D

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Document 23 f:/Week-36/BX003202/DOCUMENT LISTING FOR PROJECT BADGER/medical defense against biological material:12069615355829
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003202
Unit = OTSG
Parent Organization = HSC
Folder Title = DOCUMENT LISTING FOR PROJECT BADGER
Folder Seq # = 1
Subject = MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIAL
Document Seq # = 3
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 06-DEC-1996