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Subject: MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIAL                     

Unit: OTSG        

Parent Organization: HSC         

Box  ID: BX003202

Folder Title: DOCUMENT LISTING FOR PROJECT BADGER                                                             

Document Number:          3

Folder Seq  #:          1





                                          UNCLASSIFIED










            and possible, albeit somewhat more difficult, to induce
            tetracycline resistance. Therefore, if there is information
            indicating a biological weapon attack, prophylaxis with
            ciprofloxacin (500 mg po bid), or doxycycline (100 mg po bid)
            should begin. If unvaccinated, a single 0.5 ml dose of vaccine
            should also be given subcutaneously. Should the attack be
            confirmed as anthrax, antibiotics should be continued for at
            least 4 weeks in all exposed. In addition, two 0.5 ml doses of
            vaccine should be given 2 weeks apart in unvaccinated; those
            previously vaccinated with fewer than three doses should
            receive a single 0.5 ml booster, while vaccination probably is
            not necessary for those who have received the entire three-dose
            primary series. Upon discontinuation of antibiotics, patients
            should be closely observed; if clinical signs of anthrax occur,
            patients should be treated as indicated above. If vaccine is
            not available, antibiotics should be continued beyond 4 weeks
            until the patient can be closely observed upon discontinuation
            of therapy.




                                        BOTULISM



            CLINICAL SYNDROME

              Botulism is caused by intoxication with the neurotoxin
            produced by Clostridium botulinum. The toxin is a protein with
            molecular weight of approximately 150,000, which binds to the
            presynaptic membrane of neurons at peripheral cholinergic
            synapses to prevent release of acetylcholine and block
            neurotransmission. The blockage is most evident clinically in
            the cholinergic autonomic nervous system and at the
            neuromuscular junction.

              A biological warfare attack with botulinum toxin delivered
 the respiratory tract would be expected to cause
            symptoms similar in most respects to those observed with
            foodborne botulism.

              Clinical Features: Symptoms of botulism may begin as early
            as 3-36 hours following exposure, or as late as several days.
            Initial symptoms include generalized weakness, lassitude, and
            dizziness. Diminished salivation with extreme dryness of the
            mouth and throat may cause complaints of a sore throat.


                                            7



                                          UNCLASSIFIED

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Document 23 f:/Week-36/BX003202/DOCUMENT LISTING FOR PROJECT BADGER/medical defense against biological material:12069615355829
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003202
Unit = OTSG
Parent Organization = HSC
Folder Title = DOCUMENT LISTING FOR PROJECT BADGER
Folder Seq # = 1
Subject = MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIAL
Document Seq # = 3
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 06-DEC-1996