TRANSMITTAL OF POLICY MEMORANDA

File: 120396_sep96_decls86_0004.txt
Page: 0004
Total Pages: 6

Subject: TRANSMITTAL OF POLICY MEMORANDA                                 

Unit: OTSG        

Parent Organization: HSC         

Box ID: BX003203

Folder Title: TRANSMITAL OF POLICY MEMORANDA                                                                  

Document Number:          1

Folder SEQ  #:        179






                              DEPARTMENT OF THE ARMY
                            OFFICE OF THE SURGEON GENERAL
                                    5109 LEESBURG PIKE
                                FALLS CHURCH. VA 22041-3258


                RIEPLY TO
                ATTENTION OF
          SGPS-PSP



          MEMORANDUM FOR COL ROBERT P. BELIHAR, COM14AND SURGEON, US      )M,
                           MACDILL AIR FORCE BASE, FL 33608-7001

          SUBJECT: Policy for Use of Botulinum Vaccine


          1. Purpose: To present policy for use of botulinum vacc

          2. Discussion:

              a. Botulism is caused by the action of toxins produc
          Clostridium botulinum on neurons, preventing release of
          acetylcholine and blocking neurotransmission. A biowarfa
          attack by aerosolized botulinum toxin would be expected t       5e
          symptoms similar to those observed with food-borne botuli

              b. A pentavalent toxoid of C. botulinum types A, B,
          and E has been shown to be effective in inducing serum an       in
          levels in humans. Data suggests that limited and transie
          antitoxin levels are induced after 3 injections. There i        tle
          data available to assess immunogenicity after 1 or 2 dose
          although lower levels of antitoxin than those currently
          recommended for laboratory workers may offer protection i
          field setting.

              C. Contraindications include sensitivity to alum,
          formaldehyde, and thimerosol, or hypersensitivity to a pr       s
          dose. After the first dose, 2-4% of vaccinees report err
          or induration which peaks at 24-48 hours. Frequency of I
          reactions increases to 7-10% after the second and third c
          Mild systemic reactions are reported in up to 3%. Severe        or
          incapacitating reactions are rare. The vaccine must be
          refrigerated but not frozen.

 (3) dc         f
          0.5 ml by deep subcutaneous injection at 0, 2, and 12 we4       e
          currently recommended for preexposure prophylaxis for on:       hly
          selected individuals or groups. A dose at 52 weeks shou.'
          considered if additional vaccine becomes available.




                                           FREDERICK J. ERDTMANN
                                           Colonel, MC
                                           Chief, Preventive and Mi
                                             Medical Consultants Di

Document 6 f:/Week-36/BX003203/TRANSMITAL OF POLICY MEMORANDA/transmittal of policy memoranda:11259610133626
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003203
Unit = OTSG
Parent Organization = HSC
Folder Title = TRANSMITAL OF POLICY MEMORANDA
Folder Seq # = 179
Subject = TRANSMITTAL OF POLICY MEMORANDA
Document Seq # = 1
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 25-NOV-1996