Biological Warfare Defence Medical Guidelines

File: doc61_07.txt
Page: 07
Total Pages: 8
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FIN~L SECTION OF 3

SM~LL O.U~NTITY OF THE ~NTITOXIN IS ~Y~IL~SLE IN THE~TER ~ND WILL
SE HELD IN kESERVE FOR DOCUMENTED EXPOSURE.       REO.UESTS FOR THIS
PRODUCT SHbULD BE M~DE DIRECTLY TO THE CENTR~L COMM~ND SURGEON' S
OFFICE (COMMERCI~L C)1I-966-I-477-815C) OR 478-4466 EXT 244 OR       -
114;  T~C 9~896T. ~69 OR 77C)).  THIS IS ~~ INVESTIG~TION~L NEW DRUG
(IND) ~ND THE ~PPROPRIMTE PROTOCOL IS ~V~IL~BLE ~T THE S~ME
NUMBER.                    _________________________________________


~LTHOUGH THE FOOD ~ND DRUG ~DMINISTR~TION (FD~) H~S ~PPROVED USE
OF THIS DRUG WITHOUT INFORMED CON~ENT, WRITTEN CONSENT WILL SE
OBT~INED WHENEVER PO~cISLE.      THE V~CCINE IS ~ PENT~V~LENT, ~LUM-


P~GE C)E RHIP~~H~\\N\
~DSORSED TOXOID TH~T CONTPi INS FORM~L IN,    BEN~ETHON I UM CHLORIDE
~ND THIOMEROS~L.    TWO TO FOUR PER CENT WILL EXPERIENCE LOC~L
ERYTHEM~ OR iNDUR~TION WITH THE FIRST DOSE H ND UP TO TEN PER
CENT WITH THE SECOND.      THREE PER CENT WILL EXPERIENCE MILD
SYSTEMIC RE~CTIONS.      NO ~N~PHYL~CTIC RE~CTIONS H~VE SEEN
RECORDED.
     C.   ST~PHYLOCOCC~L ENTEROTOXIN S    (SES)
~SOUT H~LF OF ~LL I~OL~TED STR~INS OF ST~PHYLOCOCCUS ~UREUS
PRODUCE ENTEROTOXINS      OF WHICH THER ~RE PRESENTLY FIVE   (~-E)
SEROLOGIC~LLY DISTINCT TYPES.      THEY ~RE ~ M~JOR C~USE OF FOOD
POISONING ~ND SOME    (E.G.  - ENTEROTOXIN F) H~VE SEEN IMPLIC~TED
IN THE TOXIC SHOCF:: SYNDROME.   THESE REM~~r:~SLY HE~T-ST~SLE
TOXINS H~VE ~N UNr:NOWN MODE OF ~CTION,     BUT DEFINITELY INCRE~SE
INTESTIN~L PERIST~LSIS      POSSIBLY BY SYMP~THETIC ~CTIV~TION.
CENTR~L t'~ERYOUS SYSTEM EFFECT IS ~LSO SUGGESTED.
     H~bCIDENTHL ~EROS0L EXPOCUPEc TO SES H~VE PRODUCED ~ SYNDROME
OF HIGH FEYE~    t$H#:USEH~ VOMITING. flI~RRHE~. ~~D HE~D~CHE. THESE
~YMPTOMS r~RE~'~CCOMP~NIED BY H~~ LEUkOCYTOSIS WITH S~NDEMI~ HND

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